4вЂ“9 The fall in serum IgG levels may be attributed to the haemodilution during pregnancy and transplacental transfer of maternal IgG to the fetus. Reports show that the levels of IgG did not change 1вЂ“3 or decreased significantly. Studies on serum immunoglobulin levels are limited in number and showed conflicting findings. Pregnancy is associated with several physiological, hormonal and immunological changes. This finding would be of greater weight if reproduced in a larger number of subjects with multiple serial samples at fixed regular time intervals during pregnancy and postpartum. In this cross-sectional study, serum total IgE levels showed no statistically significant changes during pregnancy or postpartum. Using analysis of variance, none of these three groups showed significant change in serum total IgE level during pregnancy or postpartum. A history of allergy was positive in 98 samples, negative in 61 and unclear in 59. Serum IgE in the postpartum period also did not differ according to method of delivery. However this was not statistically significant. Postpartum serum IgE level showed a lower mean, 14.9 IU/ml during the early postpartum period (less than 30 days) compared to 30.3 IU/ml during the late postpartum period (30 days-25 weeks). The geometric mean serum total IgE was 20.5 IU/ml in the first trimester, 20.8 IU/ml in the second and 22.2 IU/ml in the third. Analysis was also done according to history of allergy. In addition, the postpartum IgE data were analysed according to the method of delivery. Serum total IgE geometric means were compared at various trimesters and postpartum. MethodsДЎ59 pregnant subjects provided 218 serum samples during various stages of pregnancy and the postpartum period. To investigate the course of serum total IgE levels during pregnancy and postpartum. Studies on serum IgE levels during pregnancy are limited. Letters to the Editor on previously published papers are welcomed.Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc. Occasionally, the opinion of an expert on a burning topic is published in the 'Point of View' The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology. Manuscripts related to clinical, epidemiological and experimental allergology and childhood immunopathology will be considered for publication. Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon PublicationsДЄllergologia et Immunopathologia is a forum for those working in the field of asthma, allergy and immunology related to childhood.

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